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Histological assessment based on liver biopsy: The value and challenges in NASH drug development

CHB patients with obesity, diabetes, metabolic syndrome, or cardiovascular disease exhibit markedly higher risks of cirrhosis and HCC, reflecting accelerated inflammation and fibrosis even in the setting of antiviral HBV control (93)

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First, dramatic Zn + depletion relieves m-ACNT suppression, enabling mitochondrial citrate catabolism

The administration options include intranasally, subcutaneously, and orally