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10.1159/000518456 63 Toms-SimP.D'MarcoL.Romero-ParraM.Tormos-MuozM

ME1 is not regulated by ATP, which indicates that it is not an energy-sensing enzyme

Chang AY, Lalia AZ, Jenkins GD, et al

Hence, a step-by-step, multimodal approach, which includes a mix of treatments and procedures targeting the melanin synthesis pathways, the anti-inflammatory environment, senescence and vascularity, should be used, along with avoidance of exacerbating factors such as UV light and hormonal contraception (Figure 3)

These trials are among the largest peptide weight loss studies ever conducted, with thousands of participants across multiple continents and diverse populations

Nature 641 , 681689 (2025)