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Though, BITC inhibits breast cancer, lesser expression of NF-B and runt-related transcription factor 2 (RUNX2) induce osteolytic bone resorption [52]

Elife 5 , e11288, (2016)

Progesterone Deficiency: Low progesterone levels, often caused by factors like birth control, Polycystic ovary syndrome (PCOS), or aging, disrupt the balance between estrogen and testosterone

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Other considerations

On the contrary, we have also experienced positive results with patients using Testosterone Undecanoate, the difference being that we use a more frequent microdose to achieve stability