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Although the Diagnostic and Statistical Manual of Mental Illnesses (DSM V) lays out criteria for diagnosis, it still relies on individual interpretation and is subject to revision

Some people report quick changes, and others feel nothing for weeks

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Minor bruising can occur and usually resolves quickly

Moreover, it is conceivable that whether this relationship holds true or not will depend on how metabolically active a given cell type is, with cell types such as hepatocytes, adipocytes, and myocytes, which are highly metabolically active, being more sensitive to nutrient fluxes than less active cell types like fibroblasts (Frayn et al., 2006)

Caffeines effects on astrocytes may also be indirectly mediated through its impact on microglia or neurons