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The manuscript presents a brief overview of regulations and examples of feedback from regulatory agencies whilst highlighting NAMs that have been successfully applied, or could be used, in a regulatory setting, either as stand-alone methods or as part of a weight-of-evidence approach to address selected endpoints

But as one 1935 American Tobacco Company pamphlet reassured its readers, The makers of Lucky Strike cigarettes deliberately refrain from these techniques because such removal of nicotine produces an emasculated product, shorn of the very qualities which give a cigarette character and appeal. Selling the cigarette has always involved selling both the illusion of choice and a product designed to preclude it

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[176] As part of the rules, e-cigarettes, e-liquids, in addition to vaping devices and accessories, are not permitted to be sold in self-service displays