e3 ubiquitin ligases mitophagy copd smoking or cigarette smoke Alterations in the molecular control of mitochondrial turnover in lung and airway epithelial cells MKK3 influences mitophagy and is

MKK3 influences mitophagy and is involved in cigarette smoke induced inflammation ScienceDirect PRKN Ser131 phosphorylation promotes cigarette smoke induced mitophagy impairment and epithelial cell senescence via MKK3 p38 MAPK activation: An in vitro and in vivo study Nicotine induced mitophagy in bronchial epithelial cells and MYST1 downregulation in cigarette smokeexposed lungs: potential mechanisms of COPD progression Molecular Biology Reports Springer Nature Link Airway Smooth Muscle Cell Mitochondria Damage and Mitophagy in COPD via ERK1 2 MAPK Ubiquitination and Acetylation in Cellular Senescence: Mechanisms, Crosstalk, and Therapeutic Implications Yu 2025 The FASEB Journal Wiley Online Library Revisiting airway epithelial dysfunction and mechanisms in chronic obstructive pulmonary disease: the role of mitochondrial damage American Journal of Physiology Lung Cellular and Molecular Physiology American Physiological Society

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