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Misconception: if tirzepatide reduces CRP, it is treating the autoimmune disease CRP reduction reflects decreased systemic inflammation, which can result from weight loss, improved metabolic health, and reduced adipose tissue, none of which specifically address autoimmune pathology

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The OxD of the cytosolic Grx1roGFP2 sensor at steady state was 0.120.01, that is, 12% of the pool of sensor molecules was in an oxidized state (Figure 1C)