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Healthy subjects in this phase 1 study who were given a 225 mg dose had a mean concentration of 22.1 g/mL at day 29 and those given 675 mg had a mean concentration of 24.1 g/mL at day 85

NNMT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to nicotinamide, influencing intracellular nicotinamide availability and interacting with NAD-associated metabolic processes

May assist in optimizing how the body utilizes energy, particularly in relation to fat metabolism

But the most dramatic impact on aging is biological

Holliday EB, Kocak-Uzel E, Feng L, Thaker NG, Blanchard P, Rosenthal DI , Gunn GB, Garden AS, Frank SJ