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For example, elevated ROS were shown to inhibit EGFR and lectin receptor endocytosis in fibroblasts, likely by preventing their ubiquitination [90]

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Hypoxia has been shown to promote the self-renewal capacity of GSCs as well as the ability to promote a more stem-like phenotype in the non-stem cell population by the up-regulation of important stem cell factors including Oct4 or Nanog (Heddleston et al., HIF-2 is likewise expressed in GSCs at oxygen levels comparable to normal in vivo levels (25%)

HNRNPA2B1 is a mediator of m6A-dependent nuclear RNA processing events

lymphoma) by suppressing the intracellular antioxidant capacity ( Another GSH inhibitorcisplatinis a key chemotherapeutic drug agent that has been widely used in the clinical treatment of various solid tumours