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The derivation from native hGH provides biological plausibility: the C-terminal region of growth hormone has been known since the 1990s to possess independent lipolytic activity separate from the growth-promoting effects mediated by intact GH and IGF-1 signaling

Mechanistic Studies Subsequent research has explored the mechanisms by which NNMT regulates metabolism, with studies demonstrating that NNMT activity reduces cellular NAD+ availability, affects SAM-dependent methylation reactions, modulates sirtuin activity, and influences adipocyte differentiation and function

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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Galarraga M, Campion J, Munoz-Barrutia A, Boque N, Moreno H, Martinez JA, Milagro F, Ortiz-de-Solorzano C

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