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Proteasome inhibitor-induced apoptosis in CLL is associated with immediate disruption of mitochondrial function

Cureus, doi: 10.7759/cureus.62684 Leton N (2024)

Valenta R, Niederberger V

Marsh et al

Abbreviations ABT: Aminobenzotriazole ALT: Alanine transaminase APAP: Acetaminophen AST: Aspartate transaminase BUN: Blood urea nitrogen CYPs: Cytochrome P450 CCl 4 : Carbon tetrachloride CLF: Cholyl-lysyl-fluorescein KIM-1: Kidney injury molecule-1 NGAL: Neutrophil gelatinase-associated lipocalin TMRE: Tetramethylrhodamine-ethyl ester OTA: Ochratoxin A References Atroshi F, Biese I, Saloniemi H et al (2000) Significance of apoptosis and its relationship to antioxidants after ochratoxin A administration in mice

However, the specific mechanisms through which altered mitochondrial dynamics regulate DKD metabolism remain unknown and require further investigation