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Iterative cycles of Autobuild (Terwilliger, 2004

Regulate oestrogen levels naturally Certain gut bacteria, often referred to as the estrobolome, help break down and recycle oestrogen in the body

While nintedanib and pirfenidone work through direct inhibition of fibrotic signaling pathways, luteolin offers a broader therapeutic approach by modulating oxidative stress and inflammation alongside its anti-fibrotic effects [150]

A key approach involves inhibiting enzymes like ACSL4, which incorporates polyunsaturated fatty acids into membranes, a critical step for ferroptosis ( 4.3 Anti-inflammatory and multitarget approaches Neuroinflammation amplifies ferroptosis via DAMPs and cytokines, creating a vicious cycle of damage ( 4.4 Innovative therapeutic platforms Emerging therapeutic platforms aim to overcome the limitations of small molecules through enhanced targeting and delivery

Trx1, a 105-amino-acid redox protein with a molecular mass of 12 kDa, is an important component of the Trx system and is mainly localized in the cytoplasm and nucleus (10,18)

identified a factor in human serum that could stimulate the release of thyroid hormone in guinea pigs and a human subject (Figure 2) (4, 5)