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Repeated measures ANOVA, followed by Bonferronis post hoc test, was used to assess changes over time

In summary, this section not only untangled the diverse molecular mechanisms by which small molecules target the regulation of MMPs to inhibit GBM invasion (involving key signaling pathways, metabolism, non-coding RNAs and ion channels), but also highlighted the considerable clinical translational potential of certain compounds [such as NP16 and novel Pt(IV) complexes] with excellent BBB penetration and in vitro/in vivo activity in overcoming GBM invasiveness (Table SIII)

[DOI] [PubMed] [Google Scholar] 58.Ersan S, Bakir S, Erdal Ersan E, et al

Brain Behav Immun

In addition, exosomal-based therapies, having low immunogenicity and high biocompatibility, for drug delivery as an effective treatment option or by inhibiting their actions as a treatment strategy have been associated with favorable results in NAFLD

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