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108 When endoplasmic reticulum stress (ERS) is severe and persistent, it can trigger apoptosis by activating the endoplasmic reticulum (ER) pro-apoptotic cysteine protease caspase-12 and inhibiting the expression of Bcl-2

Similar content being viewed by others Introduction Sickle cell disease (SCD) is one of the most common severe monogenic disorders rooted in a single base-pair point mutation of the hemoglobin -chain resulting in an abnormal hemoglobin S (HbS) [1]