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The astrocytic glutamate transporter GLT-1/EAAT2 expression is markedly reduced (Rothstein et al., 1995)

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We anticipate that elucidating the intrinsic link between the Nrf2 pathway and ferroptosis will be the key to treating lung diseases, as illustrated in Fig

Furthermore, BDNF has never entered PD clinical trials, mainly due to poor blood-brain barrier penetration, a short half-life, and the risk of abnormal synaptic plasticity (e.g., epileptiform discharges) with overexpression [62, 63]

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