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Phase I studies from the late 1980s using IGF-1 to treat Larons Syndrome (GH insensitivity) revealed effective increase in linear growth reaching adult heights using doses ranging from 80 to 240 g/kg/day [264268]

These represent different forms of vitamin B12 with distinct chemical structures and metabolic fates

2017 Dec;10:1-4

Vitamin B12 may be part of the picture, but lifestyle factors, stress, sleep quality, and other health issues can also play a role

Contraindications Given the limited safety data, conservative contraindications would include pregnancy or plans to become pregnant, breastfeeding, age under 18, severe liver or kidney disease, and any condition requiring medications with unknown interaction potential

I recently received a letter from a reader who started on disability due to her thyroid fatigue and, with the use of thiamine, was able to return back to work