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Piperine, a natural compound from black pepper, helps **slow down curcumins metabolism and enhance its transport**, supporting a dramatic increase in bioavailability

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Clofazimine is at least partially metabolised in the liver via CYP3A4 and CYP1A2, thereby TB smokers may experience increased metabolite synthesis, potentially necessitating dosage adjustments

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Again, before it can be converted to an active form that you can use and absorb, your body must use a methylation reaction to cleave the cyanide out