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Extensive research has identified direct targets of curcumin in humans, including protein kinases and reductases, proteasomes, inflammatory molecules, transport proteins, DNMTs, and metal ions (Sohn et al., 2021)

Factors such as poor diet, chronic stress, environmental toxins, and aging can deplete glutathione levels in the body

Studies have shown that HCC and pancreatic cancer, among others, highly express CPS1, a urea cycle enzyme that promotes survival by enhancing ammonia detoxification (135, 203)