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Risk factors for deficiency include long-term antacid medications use, metformin therapy, GI disorders, surgery, and vegetarian/vegan diets

Its exceptional stability (acid-pH resistance, enzymatic resistance outperforming most bioactive peptides) enables partial oral bioavailability and a systemic half-life compatible with once-daily administration

and serum folic acid and cobalamine levels were 1.7 ng/ml (normal, 3.612.9 ng/ml) and 397 pg/ml (normal, 233914 pg/ml), respectively

Finally, as detailed clinical indications were not consistently available in the national administrative dataset, future research should employ a nested casecontrol design to enable more precise characterization of these variables

Its estimated that roughly 20% of people over 60 in the United States and the United Kingdom are deficient in vitamin B12 (1)

Raina Kishan, MS4 Christine D