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GHRH Receptor Binding CJC-1295 binds to GHRH receptors on somatotroph cells in the anterior pituitary, stimulating the synthesis and release of growth hormone

In line with this finding, GH receptor deficient mice have reduced relative liver weight[94], and transgenic mice overexpressing GH presented disproportional growth of the liver, whereas this is less apparent in mice overexpressing IGF-I[95, 96]

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