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4.2.6 Targeting ferroptosis for the treatment of AKI Given that ferroptosis is extensively involved in the occurrence and development mechanisms of various types of AKI, targeting the ferroptosis pathway may be a novel strategy for preventing and treating AKI

Nature (2019) 566:4036

Some of these methods include incorporating microgrooves into the interior surface of the conduit, filling the lumen with hydrogels, or using tissue-derived extracellular matrix (ECM) 13,14,15,16,17

(Reference Sterne, Savovic and Page19) This tool assesses potential sources of bias with regard to the following methodological domains: the randomisation procedure

Reconstitution: Reconstitute the full vial with 1ml or 2ml of bacteriostatic water, depending on desired concentration

Work up to 10 drops twice a day (10mg) by the end of week 2