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Knockdown of long non-coding RNA HOTAIR promotes bone marrow mesenchymal stem cell differentiation by sponging microRNA miR-378g that inhibits nicotinamide N-methyltransferase

Increased NNMT activity has been observed in several metabolic research models and is associated with altered energy expenditure and disrupted NAD+ recycling

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This mechanism is the focus of most current research interest, particularly in studies on stubborn visceral fat and metabolic regulation

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