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The drug was been approved since 1959 and is used for the following indications: References Mechanism of Action 1,2 Phentermine predominantly acts in the central nervous system (CNS), within the hypothalamus and limbic systems, where it works on appetite regulation

According to the National Institute of Diabetes and Digestive and Kidney Diseases, adults who are overweight or obese should lose 5% to 10% of their body weight within 6 months for weight loss success and better outcomes (12)

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However, they need to make sure the supplement provides acceptable amounts of vitamin B12 made from high-quality ingredients