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Patients should contact their GP urgently if neurological symptoms worsen, new symptoms develop, or signs of liver decompensation appear, as this may indicate inadequate treatment response or disease progression requiring specialist review

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However, vaccine performance is affected by the constant acquisition of viral mutations due to the inherent high error rate of virus RNA-dependent RNA polymerase (RdRp) and the existence of a highly variable receptor-binding motif in the spike (S) protein

If you have neurological symptoms eg tingling, pins and needles, insect crawling sensation, burning sensation, electric shock sensation, muscle twitching, flickering eyelids, limb jerks, migraine, memory problems, balance problems, difficulty getting the right word out, clumsiness, dropping things, bumping into things, problems with spatial awareness, incontinence etc

A small dedicated section of the fridge works best

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