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Some antioxidants, for example, may theoretically interfere with the controlled oxidative environment that supports certain stages of follicular development

50,51 This energy deficiency triggers the collapse of the mitochondrial membrane potential ( m ) and the release of proapoptotic factors, which activate the caspase cascade and induce apoptosis or senescence

Other glutamate receptors, including kainate receptors (KARs) and metabotropic glutamate receptors, can control long-term and short-term synaptic plasticity [76, 77]

Finally, pharmacological research is needed to ensure that drugs are delivered to the necessary organs, such as the inflammatory joints of RA, with optimum safety and efficiency in a wide range of autoimmune diseases

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doi: 10.1016/j.bcp.2007.07.007