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The prokaryotic enzyme DsbB may share structural features with eukaryotic disulfide bond forming oxidoreductases

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Western blot analysis of thoracic aorta proteins showed that the classic aging markers P21 and P16 were significantly downregulated following FOXO4-DRI treatment, whereas the expression levels of the cell proliferation marker Ki-67 and Lamin B, a key protein involved in nuclear structural stability, were markedly upregulated (Figure 1A)

It has two forms: one is in an oxidized state and the other in a reduced state

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