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The conceptual basis of 5-FU has been used to develop a thymidine analog, trifluorothymidine (TFT), as discussed below

Further studies linked the susceptibility to viral-induced myocarditis with a deficiency of GPx1, as GPx1 knockout (GPx1 / ) mice on a normal selenium diet were susceptible to viral-mediated myocarditis whereas wildtype (GPx1 +/+ ) mice were protected from viral-induced cardiac damage [28]