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Free Radic Biol Med 99:259272 Sivandzade F, Prasad S, Bhalerao A, Cucullo L (2019) NRF2 and NF-B interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches

It was first discovered in surviving neurons of Alzheimer's disease patients, sparking research into neuroprotection and age-related cellular pathways