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The addition of GSH or expression of Grxs 1 and 2 significantly improves mutant SOD1 solubility in cell culture, whereas reducing the levels of intracellular GSH decreases SOD1 solubility, suggesting that GSH reduction promotes the aggregation of mutant SOD1 (Guareschi et al., 2012)

Cardiac arrhythmias secondary to hypokalaemia during initial therapy have been reported

Food and Drug Administration (FDA) and the European Medicines Agency (EMA) and has attracted considerable attention for drug nanoparticle development (Kumar and Kumar, 2019

However, more recently, GSNO has begun to be used as it is considered to be a more physiological NO donor (Liu et al., On the other hand, the involvement of NO in plant reproductive biology has been reported (Bright et al., Lilium longiflorum , Arabidopsis thaliana , and Paulownia tomentosa (Prado et al., Pinus bangeana in a dose-dependent manner (Wang et al., in vitro germination has shown the presence of GSNO (unpublished data) whose content closely correlated with the NO content previously reported (Zafra et al., GSNOR gene expression

Early alignment of pre-clinical endpoints with clinically meaningful outcomes accelerates translation