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According to Xiao et al (63), iron ions accelerate AS by generating free radicals, which induce endothelial cell apoptosis and oxidize LDL, promoting macrophage uptake

doi: 10.3390/jof8121275 198 TangX.WuJ.WuW.ZhangZ.ZhangW.ZhangQ.et al

The switch between these two states occurred relatively fast because we did not register any intermediate states or smooth shifts in biophysical parameters at different values of oxidative stress

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Some well-known causes of glutathione depletion are as follows