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for example, donepezil has been reported to interact with both P -gp and BCRP, underscoring how BBB efflux biology may influence brain drug availability and therapeutic response ( In AD, BBB integrity is often altered due to vascular dysfunction, inflammation, and cerebral amyloid angiopathy (Sweeney et al., 2018

Carbon nanotubes and central nervous system: environmental risks, toxicological aspects and future perspectives

The available observational studies reported even higher short-term efficacy rates

At the same time, we strive to foster a community where faculty, trainees, and staff find meaning, purpose, and fulfillment in their work

Far from being a single procedural step, a FIH trial is built on a broad body of scientific, regulatory and operational work designed to ensure that the transition from preclinical research to human investigation takes place within a rigorous framework focused on safety, quality and evidence generation

Doing it correctly on Monday but carelessly on Wednesday produces erratic blood levels and unreliable results