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*Correspondence: Jin Sun, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The metabolism of these compounds by GT positive tumor cells should produce high local concentrations of bioactive and membrane permeable metabolites that would then block tumor cell proliferation and eventually tumor growth

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One of its main components salvianolic acid A acts as an antioxidant by reducing Ang-II-induced NADPH oxidase-4 (Nox4), which decreases reactive oxygen species and, as a result, suppresses Src and Akt activation

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