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It is conditionally essential the body can produce it from methionine, but the pathway has limits

Neuron 52(1):155168

Adv Cancer Res 136:4983

Connors, N

Interferon beta-treated DCs induce the gene expression of IL-12p35 and IL-27p28, which suppress the differentiation of Th17 cells and induce IL-10 secretion through the activation of STAT1 and STAT3 in MS [151]