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It happens when there arent enough red blood cells to carry oxygen throughout the body, whether because your body isnt making enough of them or because they are damaged in some way due to factors that include abnormal hemoglobin or being deficient in iron, which is needed to make hemoglobin

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J Am Coll Cardiol 43:17311737 Amitai N, Markou A (2009) Chronic nicotine improves cognitive performance in a test of attention but does not attenuate cognitive disruption induced by repeated phencyclidine administration

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it's about understanding the synergy between your tobacco's moisture, your packing density, and your machine's limitations