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By bypassing the digestive tract, IM injections offer a level of bioavailability that standard capsules simply cannot match

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SHMT2 has been reported to be highly expressed in pseudopalisading cells surrounding ischemic necrotic foci in GBM, suppressing PKM2 activity and limiting pyruvate entry into the TCA cycle [30]

Zhang Q-F, Wang S, Zhang H et al (2022) Effects of alpha-lipoic acid on sperm quality in patients with varicocele-related male infertility: study protocol for a randomized controlled clinical trial

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This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function