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In parallel, we performed a FACS-based CRISPR screen using a library of UPS-focused sgRNAs and a dual fluorescence stability reporter for the short isoform of BRD4, BRD4(S) (KBM7 cells expressing a BRD4(S)-TagBFP-P2A-mCherry construct) (Fig

Highlighted Study: In a 2025 clinical study, NAC supplementation significantly improved cognitive performance and antioxidant capacity while reducing inflammation and oxidative stress markers - suggesting direct neuroprotective benefit (PMC11852533)

This suggests that in the dataset analysed, reported GDP consistently varies sufficiently smoothly to be captured by a thin plate spline

We treated the mold and yeast cultures of T

Prior study showed that deficiency of Sentrin/SUMO-specific protease 2 (SENP2) resulted in hyper-SUMOylation of multiple potassium channels and neuronal hyperexcitability, finally triggering spontaneous seizures and sudden death [78, 79], which suggests that sumoylation is vital for epilepsy

Reduces Melanin Production Glutathione inhibits the enzyme tyrosinase, which is responsible for producing dark pigment (eumelanin)