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[3] Chang CH, Tsai WC, Hsu YH, Pang JH

Some commenters suggested that CMS use an alternative term to refer to these technologies, such as Software as a Medical Device in conformance with FDA definitions, or clinical decision support tools. Some commenters provided suggestions on how CMS should categorize these types of services in terms of payment

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This mini review summarizes neurotrophin biology relevant to bone sarcoma, delineates mechanisms by which these pathways reprogram immune and stromal compartments, and evaluates therapeutic strategies ranging from ligand/receptor blockade to clinically available TRK inhibitors, with the objective of defining tractable approaches to restore immune competence in this disease

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