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Earlier, it was shown that subcutaneous administration of MT-II, (Ac-Nle-c[Asp-His-D-phe-Arg-Trp-Lys]-NH 2 ), a potent synthetic cyclic heptapeptide, containing amino acids 4 10 of -MSH and ACTH that represent the core melanocortin receptor binding region (Al-Obeidi et al ., 1989

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