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The basis of this assay was to react GSS with IAM-TPP to generate GSS-CAM-TPP, which can readily and sensitively be detected by LC-MS/MS due to its positively charged TPP MS tag (Supplementary Fig

Rochette et al., 2023)

Furthermore, while Nrf2 is a promising therapeutic target, its systemic activation must be carefully evaluated due to its pleiotropic roles in other developmental processes