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Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts[J]

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and (ii) off-target resistance caused by the activation of bypass signal transduction resulting from the amplification of the ERBB family of receptor tyrosine kinase genes, BRAF amplification, KRAS amplification, and KRAS mutations [148]

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