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doi: 10.3389/fphar.2021.636154 120 ZhouYFangLJiangLWenPCaoHDHeWCet al

Overall, DSIP appears relatively well-tolerated, but there are important considerations and potential side effects to be aware of

Moreover, the metabolites of arginine play an important role in maintaining the intestinal barrier and promoting the repair of the gastrointestinal mucosa ( + cells and activate CD4 + T lymphocytes, leading to inflammatory/immune-mediated diseases ( + /CD8 + in different parts of intestinal mucosal immunity decreased significantly after 8 weeks of TGP administration in this study, suggesting that TGP may regulate lymphocytes in intestinal mucosal immunity and epithelial barrier through glutathione metabolism, thereby exerting an anti-RA effect