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One of the central mechanisms by which tumors achieve this immune evasion is through the induction of IDO1 activity and the subsequent depletion of tryptophan and accumulation of kynurenine ( Figure 1A ) ( Tryptophan depletion alone has significant effects on immune cell function since T cells, particularly effector T cells, are highly sensitive to tryptophan availability

Folic acid and the prevention of neural tube defects (NTDs) challenges and recommendations for public health

Quinti, L

Circulation (2005) 112(3):41622