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Reactive Oxygen Species Regulate FSH-Induced Expression of Vascular Endothelial Growth Factor via Nrf2 and HIF1 Signaling in Human Epithelial Ovarian Cancer

In that sense, estrogen positively regulates the expression of proteins related to mitochondrial biogenesis, such as the nuclear respiratory factor-1 (NRF-1) and the peroxisome proliferator-activated receptor-gamma coactivator 1 (PGC-1) (Kemper et al., 2013