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To test this theory, a research reprogrammed human fibroblast cell lines derived from the young and from the old to a state similar to that of embryonic stem cells

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2007 Riggio, Jay

Biochim Biophys Acta 1996

The investigation of 25 curcumin analogs surprisingly showed that dihydroxylated curcumin, monohydroxylated demethoxycurcumin, and mono- and di-hydroxylated bisdemethoxycurcumin, increased NEP activity, but curcumin did not

In the study by Fontcuberta-PiSunyer et al., human fibroblasts were directly reprogrammed using adenoviral vectors delivering NEUROG3, PDX1, and MAFA, followed sequentially by PAX4 and NKX2-2