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NU-refinement for each class yielded maps with resolutions of 3.92 , 4.35 , 3.85 , and 3.82 , respectively

Examples of DAMPs include high-mobility group box 1 (HMGB1) and heat shock proteins (HSPs), which, together with other pro-inflammatory mediators, contribute to the disruption of the bloodbrain barrier (BBB) (19)

Current and future therapeutic strategies for Alzheimer's disease: an overview of drug development bottlenecks

J Biol Chem 272(46):29222-29228, 1997

Although HNPs have direct and potent antimicrobial activities, 185 these peptides also control infection during acute infection by modulating various immune activities such as chemotaxis, phagocytosis, and cytokine induction

Elucidating the function of LLPS in autophagy-dependent cell death could pave the way for innovative approaches to studying embryonic development, unraveling the pathogenesis, and improving therapeutic strategies for Alzheimers disease, as well as inhibiting protective autophagy to enhance autophagy-dependent cell death-based anti-tumor therapies