Reversing aging rapidly with short-term calorie restriction
Abbreviations 6MWD: 6-Minute Walk Distance 17-HSD1: 17-hydroxysteroid dehydrogenase type 1 A.D.: Anno Domini AC-T: Doxorubicin and Cyclophosphamide followed by Taxane AEs: Adverse events AIF: Apoptosis-inducing factor AIs: Aromatase inhibitors ALP: Alkaline phosphatase ALT: Alanine aminotransferase Ang: Angiopoietin ANT: Anthracycline-based chemotherapy AP-1: Activator protein-1 AVLT: Auditory-verbal learning test ASCT2: Cysteine transporter 2 AST: Aspartate aminotransferase ATG: Autophagy-related proteins B.C.: Before Christ BC: Breast cancer BCRL: Breast cancer-related Chronic Lymphedema BD-II: Beck depression inventory-II BDNF: Brain-derived neurotrophic factor BFI: Brief fatigue inventory BGP: Bone gla protein BMD: Bone mineral density BPI: Brief pain inventory BPI-SF: Brief pain inventory-short form BPI-WP: Brief pain inventory worst pain CA: Cancer associated antigens CAF: Cyclophosphamide + Doxorubicin + Fluorouracil CBR: Clinical benefit rate CBT-I: Cognitive behavioral therapy for insomnia CDKs: Cyclin-dependent kinases CDT: Comprehensive decongestive therapy CEA: Carcinoembryonic antigen CEF: Cyclophosphamide epirubicin fluorouracil CI: Confidence interval CINV: Chemotherapy-induced nausea and vomiting CIPN: Chemotherapy-induced peripheral neuropathy CKI: Compound kushen injection CK-MB: Creatine kinase-mb CTC: Circulating tumor cells cTnI: Cardiac troponin I DCR: Disease control rate DDSBs: DNA double strand breaks DFS: Disease-free survival DCIS: Non-invasive ductal carcinoma in situ ECM: Extracellular matrix ECOG-PS: Eastern cooperative oncology group performance status EMT: Epithelialmesenchymal transition EOT: End of treatment ER: Estrogen receptor FA: Fatty acid FACT: Functional assessment of cancer therapy FACT-B: Functional assessment of cancer therapy-breast FACT-COG: Functional assessment of cancer therapy - cognitive function FACT-GOG-Ntx: Functional assessment of cancer therapy - gynecologic oncology group-neurotoxicity FAO: Fatty acid oxidation FasL: Fas ligand FASN: Fatty acid synthase FEER: Erythrocyte immune adherence enhancing rate FEMT: Five-element music therapy FGFR: Fibroblast growth factor receptor FOXM1: Forkhead box protein M1 GB: Gallbladder meridian GAP: Good Agricultural Practice GCP: Good Clinical Practice GMP: Good Manufacturing Practice GLUT: glucose transporter GLP: Good Laboratory Practice GPNA: L--glutamyl-p-nitroanilide GPX4: Glutathione peroxidase 4 GSH: Glutathione HADS: Hospital anxiety and depression scale HAMA: Hamilton anxiety scale HER2: Human epidermal growth factor receptor 2 HFNS: Hot flushes and night sweats HIF-1: Hypoxia-inducible factor-1 HO-1: Heme oxygenase-1 HR: Hormone receptor HT: Heart meridian IDC: Invasive ductal carcinoma ILC: Invasive lobular carcinoma IQR: Interquartile range ISI: Insomnia severity index K/KD/KI: Kidney meridian KPS: Karnofsky performance status LC3: Microtubule-associated protein 1 A/1B-light chain 3 LI: Large intestine meridian LN: Laminin LncRNAs: Long non-coding RNAs LR: Liver meridian LU: Lung meridian LVEF: Left ventricular ejection fraction MD: Mean differences MDA: Malondialdehyde MDM2: Mouse doubleminute 2 homolog MDSCs: Myeloid-derived suppressor cells MMP: Matrix metalloproteinase MRS: Menopause rating scale NK: Natural killer cell NRS: Numeric rating scale NT-proBNP: N-terminal pro-B-type Natriuretic Peptide OR: Odds ratio ORR: Objective response rate OS: Overall survival OXPHOS: Oxidative phosphorylation P2RX7: P2X purinoceptor 7 PICP: Procollagen type I carboxy-terminal propeptide PC: Pericardium meridian PCIII: Procollagen type III PD-1: Programmed death receptor 1 PD-L1: Programmed death ligand 1 PFS: Progression-free survival PFS-R: Piper Fatigue Scale-Revised PNQ: Patient neurotoxicity questionnaire PP2A: Protein phosphatase 2 A PPARG: Peroxisome proliferator-activated receptor gamma PR: Progesterone receptor PSQI: Pittsburgh sleep quality index Rb: Retinoblastoma-associated proteins RBC-ICR: Red blood cell immune complex rosette RCT: Randomized controlled clinical trials REM: Rapid eye movement ROS: Reactive oxygen species RR: Relative risk s-CTX: Serum C-terminal telopeptide of type I collagen SE-electin: Soluble E-selectin SIO: Society for integrative oncology SJ/TE: Triple energizer/sanjiao meridian Skp2: S-phase kinase-associated protein 2 SMD: Standard mean difference SOD: Superoxide dismutase SP: Spleen meridian s-PINP: Serum N-terminal propeptide of type I procollagen SREBP1: Sterol regulatory element binding protein 1 ST: Stomach meridian TAMs: Tumor-associated macrophages TBIL: Total bilirubin TCM: Traditional Chinese Medicine TEAS: Transcutaneous electrical acupoint stimulation TFR: Transferrin receptor Th: T helper cell TLR4: Toll-like receptor 4 TME: Tumor microenvironment TPS: Tissue polypeptide specific antigen TrxR: Thioredoxin reductase TSGF: Tumor specific growth factor TR: TGF- receptor ULK1/2: Unc-51-like kinase VAS: Visual analog scale VEGF: Vascular endothelial growth factor VEGFR: Vascular endothelial growth factor receptor WASO: Wake after sleep onset WHOQOL-BREF: World Health Organization Quality of Life-BREF WM: Western Medicines References Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A
Blood (2016 ASH Annual Meeting Abstract) 128(290), 2016
Patients were diverse regarding race/ethnicity (36% non-Hispanic White, 36% Hispanic, 27% Black), cirrhosis etiology (50% hepatitis C virus, 25% nonalcoholic steatohepatitis, 20% alcohol), and tumor stage (41% early-stage BCLC stage 0/A and 59% BCLC stage B, with 41% being within Milan Criteria)
Your digestive system's ability to absorb nutrients limits the effectiveness of oral supplements
51 Special Issue D, 268272 (2019) S
