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Data from the United States and validated in the 1990s provided a crude annual incidence of 5.7 per 100 000 women and 2.5 per 100 000 men

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Standard (Evidence Strength: Grade B) One RCT reported that an 18 week protocol of sequential antibiotic administration resulted in 20% of the treatment group reporting 50% or greater symptom improvement compared to 16% of the placebo group a nonsignificant difference

Consistent use of broad-spectrum SPF is essential for optimal results