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Glycine as a collagen precursor in pulmonary fibrosis Glycine, which constitutes approximately one-third of the amino acids in collagen, plays a pivotal role in ECM accumulation during pulmonary fibrosis [17]

Also, Nrf2 supports cell proliferation by inducing metabolic reprogramming towards anabolic pathways, augmenting purine synthesis, and influencing the pentose phosphate pathway (PPP)

[DOI] [PubMed] [Google Scholar] 165.Pawar S., Koneru T., McCord E., Tatiparti K., Sau S., Iyer A.K

Interestingly, this effect is not achieved by affecting the deubiquitinase (DUB) activity of OTUB1 but by impairing its noncanonical activity, binding to the E2 enzyme UBC13[206]