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Diagnosis, natural history, and management in vascular Ehlers-Danlos syndrome

Research has also examined its role in upregulating matrix metalloproteinase (MMP) activity alongside their inhibitors (TIMPs), suggesting a finely balanced role in extracellular matrix remodelling rather than simple collagen deposition

Hence, estrogen pathways lead to an inflammatory state and disturbances in the immune environment, which affect morphological and biochemical changes associated with endometrial tolerance, resulting in pregnancy outcomes

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