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Such NPs encapsulate hydrophilic and hydrophobic drugs, protect them from degradation, and enhance their delivery across the BBB (90)

Biochim Biophys Acta 1830:31433153 Makar TK, Nedergaard M, Preuss A, Gelbard AS, Perumal AS, Cooper AJ (1994) Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain

To the best of our knowledge, this is the first study demonstrating that Klotho may protect against oxidative stress via inhibition of the IGF1R/PI3K/AKT pathway in the heart IRI model

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However, In the xenograft model, the inhibition of GPX4 restrain tumor regrowth after discontinuation of 5-FU treatment (Zhang X